Calcipotriene
- Product Name
- Calcipotriene
- CAS No.
- 112828-00-9
- Chemical Name
- Calcipotriene
- Synonyms
- Carpotriol;Calcipotrien;CALCIPOTRIOL;Calcipotriene;Calcipotriene API;Calcipotriene USP/EP/BP;Calcipotriene/calcipotriol;24-CYCLOPROPYL-(1ALPHA,3BETA,5Z,7E,22E,24S)-9,10-SECOCHOLA-5,7,10(19),22-TETRAENE-1,3,24-TRIOL;(1R,3S,5Z)-5-{2-[(4E)-1-[(2R,3E,5R)-5-CYCLOPROPYL-5-HYDROXYPENT-3-EN-2-YL]-7A-METHYL-HEXAHYDRO-1H-IN;(1r,3s,5z)-5-[(2e)-2-[1-[(e,2r,5r)-5-cyclopropyl-5-hydroxypent-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1h-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
- CBNumber
- CB1412712
- Molecular Formula
- C27H40O3
- Formula Weight
- 412.6
- MOL File
- 112828-00-9.mol
Calcipotriene Property
- CAS DataBase Reference
- 112828-00-9(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H311Toxic in contact with skin
H331Toxic if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P311Call a POISON CENTER or doctor/physician.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P361Remove/Take off immediately all contaminated clothing.
P363Wash contaminated clothing before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 10009599
- Product name
- Calcipotriol (hydrate)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $56
- Updated
- 2021/12/16
- Product number
- 10009599
- Product name
- Calcipotriol (hydrate)
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $252
- Updated
- 2021/12/16
- Product number
- 10009599
- Product name
- Calcipotriol (hydrate)
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $448
- Updated
- 2021/12/16
- Product number
- 10009599
- Product name
- Calcipotriol (hydrate)
- Purity
- ≥98%
- Packaging
- 500mg
- Price
- $1960
- Updated
- 2021/12/16
- Product number
- 2700
- Product name
- Calcipotriol
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $889
- Updated
- 2021/12/16
Calcipotriene Chemical Properties,Usage,Production
Uses
Antipsoriatic.
Indications
Calcipotriene (calcipotriol) is a synthetic vitamin D3 derivative that is useful for
the treatment of patients with moderate plaque psoriasis. Its effects are comparable
with those of class II topical steroids, without the associated adverse effects.
Its mechanism of action involves both induction of terminal differentiation of
keratinocytes and inhibition of keratinocyte production. It should be applied to
the face with care, as this region is more susceptible to irritation, burning, and
itching, as seen in approximately 10% of patients. Other adverse effects include
erythema, peeling, xerosis, dermatitis, or worsening psoriasis in 1% to 10% of
patients. Fewer than 1% of patients experience hypercalcemia, atrophy, hyperpigmentation,
or folliculitis. Allergic contact dermatitis to calcipotriene has been
reported.
Most patients demonstrate improvement after 2 weeks; 70% of patients
improve after 8 weeks, with 10% showing complete clearing. It should be avoided
in patients with documented impairment in calcium metabolism, hypercalcemia,
vitamin D toxicity, or history of renal stones.
Calcipotriene may be used as an adjuvant with psoralens plus ultraviolet A
(PUVA) and ultraviolet B (UVB). Pretreatment with or subsequent addition of calcipotriol
to PUVA reduces the cumulative doses of UVA needed to achieve >75%
reduction in severity and distribution of psoriasis.
Definition
ChEBI: Calcipotriol is a seco-cholestane that is 26,27-cyclo-9,10-secocholesta-5,7,10,22-tetraene carrying additional hydroxy substituents at positions 1, 3 and 24. It is used (as its hydrate) in combination with betamethasone dipropionate, a corticosteroid, for the topical treatment of plaque psoriasis in adult patients. It has a role as a drug allergen and an antipsoriatic. It is a member of cyclopropanes, a secondary alcohol, a triol, a hydroxy seco-steroid and a seco-cholestane.
brand name
Dovonex (Leo).
Calcipotriene Preparation Products And Raw materials
Raw materials
Preparation Products
Calcipotriene Suppliers
View Lastest Price from Calcipotriene manufacturers
- Product
- Calcipotriene 112828-00-9
- Price
- US $10.00-2.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-28
- Product
- Calcipotriene 112828-00-9
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-25
- Product
- Calcipotriene 112828-00-9
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1Kg
- Purity
- 99.9%
- Supply Ability
- 200tons
- Release date
- 2024-04-09